When two people talk, the imaginary line connecting them is called the line of action. Keep the camera on one side of it, and no matter how you cut between shots, subject A stays on the left of frame and B stays on the right.
Cross that line mid-scene, and the next cut suddenly flips A and B's positions. Cut the two shots together and the spatial sense breaks — it reads like the characters teleported, and the audience loses track of where everyone is.
When a scene genuinely needs to cross the line — a multi-camera shoot, a scene transition — directors bridge it with a neutral shot taken right on the axis, or a camera move that physically tracks across it, so the reset feels motivated instead of jarring.
When to use
Follow it any time a conversation or interview is cut across multiple shots. Crossing it on purpose to disorient the audience is a real technique, but a rare one.