Dyslexic readers often confuse similar letters or words and lose their place on a line. Tight letter spacing, cramped line height, and the ragged word gaps that justified text produces all make this worse. WCAG 1.4.12 (Text Spacing) requires that content survive a user stylesheet setting line height to 1.5×, paragraph spacing to 2×, letter spacing to 0.12em, and word spacing to 0.16em without breaking.
The common prescription in practice: **left-align** (justify creates irregular word gaps), keep the measure to 45–75 characters, set line height to 1.5× or more, avoid italics (the slant adds confusion) and use real bold for emphasis instead. Special fonts (OpenDyslexic and similar) are sometimes claimed to help, but the research is mixed — the spacing rules above are the more reliable fix.
Left is a dense, justified paragraph; right is the same paragraph reset with left alignment and generous letter spacing, line height, and measure.
When to use
Don't use text-align: justify on body paragraphs. Keep line height at 1.5 or more, and cap line length with a max-width in ch units so no line runs past ~75 characters.